Dextran Sulfate Sodium Induced Colitis Model
Dextran Sulfate Sodium (DSS) is a sulfated polysaccharide with anticoagulant properties to induce colitis.
It is believed that DSS is directly toxic to gut epithelial cells of the basal crypts and thus harm the integrity of the mucosal barrier.
The clinical observation of DSS treated animals are very similar to human IBD pathologies.
STUDY ENDPOINT
- MPO levels
- DAI and Macroscopic scores
- Cytokine analysis and other inflammatory markers (TNFa, IL-1b, SAA, KC)
- Blood collections and analysis (Fe2+ and Hemoglobin)
- Stool collections (NGS analysis of microbiota)
- Tissue collections
- Intestinal permeability (FITC-Dextran)
- Histopathologic analysis
VALIDATION DATA
